Advancing Pharmaceutical Research: The Role of Mass Spectrometry in Drug Discovery and Development
In modern pharmaceutical science, precision determines success. The mass spectrometer has become indispensable in every phase of drug discovery — from molecular screening to quality control — providing deep insights into chemical structure and behavior.
During the early stages of research, mass spectrometry helps identify potential drug candidates by determining molecular weights and structural characteristics. Combined with high-performance liquid chromatography (LC-MS), it separates complex mixtures and pinpoints target molecules among thousands of compounds.
In drug metabolism studies, mass spectrometry tracks how a compound breaks down within the body. It identifies metabolites, reveals enzymatic pathways, and helps predict potential toxicity. Such analysis ensures that drugs remain effective and safe across dosage levels.
Pharmacokinetics relies heavily on tandem mass spectrometry (MS/MS) for quantifying drug concentrations in blood and tissues. This precision informs dosing regimens and helps researchers understand how drugs distribute and clear from the body.
Quality assurance is another critical area. Regulatory…